Catheter-related bloodstream infection (CRBSI) is a leading cause of healthcare-associated infections in preterm infants.
Strategies to reduce CRBSI include:
1) Maximal aseptic precautions during line insertion with standardised checklists
2) Limited frequency of accessing or blood collection from the central line
3) Vigorous disinfecting of the line ‘hub’ at the time of entry or disconnection
4) Ensuring integrity of the line dressing and frequent evaluation of catheter site for signs of infection
5) Vancomycin line ‘locks’ – more information is needed on ideal duration and dosages, and safety profile from larger trials
6) Removal of the catheter when there is a positive culture, or if it is no longer needed