Tip 150: oxygen and ROP

Giving supplemental oxygen in preterm infants with incompletely vascularised retina causes hyperoxia and vasoconstriction. This in turn may lead to local hypoxia, up‐regulation of vascular endothelial growth factor, and excessive proliferation of new vessels and fibrous tissue that invades the vitreous. Contraction of fibrous tissue can result in retinal detachment.

Reference: Tin et al, Optimum Oxygen Therapy in Preterm Infants, Arch Dis Child Fetal Neonatal Ed. Mar 2007; 92(2): F143–F147

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