This study compared low and high haemoglobin thresholds for packed red blood cell (RBC) transfusion in premature infants <1000g. Thresholds were decided by days of age, type of sample and the presence or absence of respiratory support. The high thresholds were 20g/L higher.
There was no statistical difference in death or survival with major morbidity (CLD, ROP, brain injury) between the groups. Thus the higher threshold group had more blood transfusions with no overall benefit and no statistical increase in complications.
Reference: Kirpalani, H., Whyte, R.K., Andersen, C., et. al., 2006. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. Journal of Pediatrics; 149(3): 301-307. (Study included 451 infants.)
First published: 14/11/13