Tip 240: acute liver failure

Acute liver failure in neonates is not strictly defined. A suggestion is: “a multi-system disorder in which severe impairment of liver function, with or without encephalopathy, occurs in association with hepatocellular necrosis in a patient with no recognised underlying chronic liver disease”.

It is rare, with mortality around 70%.

Reference: Dhawan, A., & Mieli-Vergani, G. (2005). Acute liver failure in neonates. Early Human Development; 81: 1005—1010.

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