Tip 137: chronic lung disease 2

The aetiology of CLD is multifactorial, involving both antenatal and postnatal factors, including:

  • Genetic predisposition
  • Chorioamnionitis
  • Fetal growth restriction <28/40
  • Prematurity, especially 23-32/40
  • Volutrauma and barotrauma from mechanical ventilation
  • Oxygen toxicity causing cellular damage
  • Late surfactant deficiency
  • Postnatal sepsis, especially candidaemia

References: Adams, J.M., Stark, A.R., 2013. Pathogenesis and clinical features of bronchopulmonary dysplasia. UpToDate. Accessed on 27th June 2014. 

Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

First published: 09/07/14

This entry was posted in Prematurity, Respiratory. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.