The following all increase the risk of fractures in association with osteopenia (or metabolic bone disease) of prematurity:
- Taking >30 days to establish full enteral nutrition
- Conjugated hyperbilirubinaemia
- Chronic lung disease
- Receiving chronic furosemide
The most common period for fractures is at 10 – 11 weeks’ of age.
Bishop N. Metabolic bone disease. In Rennie J, Rennie & Roberton’s Textbook of Neonatology, 5th edition, 2012. Elsevier: London.