Tip 248: osteopenia of prematurity 2

The following all increase the risk of fractures in association with osteopenia (or metabolic bone disease) of prematurity:

  • NEC
  • Taking >30 days to establish full enteral nutrition
  • Conjugated hyperbilirubinaemia
  • Chronic lung disease
  • Receiving chronic furosemide

The most common period for fractures is at 10 – 11 weeks’ of age.


Bishop N. Metabolic bone disease. In Rennie J, Rennie & Roberton’s Textbook of Neonatology, 5th edition, 2012. Elsevier: London.

Bishop, N., Sprigg, A., & Dalton, A. (2007). Unexplained fractures in infancy: looking for fragile bones. Archives of disease in childhood92(3), 251-256.

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