Tip 33: congenital cytomegalovirus (CMV)

In the UK, 50% women in antenatal clinics are seropositive for CMV. Incidence of congenital CMV infection is ~3 in 1,000 live births. Placental transmission rates are ~40% during primary infection and 1% for reactivated infection. The earlier the gestation at transmission, the worse the prognosis.

>90% infants are asymptomatic but can still develop sensorineural hearing loss.

Other symptoms/signs are: IUGR, microcephaly,  thrombocytopenia, jaundice, hepatitis, pneumonitis, periventricular calcification, chorioretinitis and cataracts.

Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

Advertisements
This entry was posted in Antenatal, Congenital anomalies, Infection. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s