Tip 50: surfactant for RDS

Using surfactant early (<2h age vs. late) in preterm infants with RDS requiring ventilation leads to reduced:

  • pneumothorax (RR 0.69)
  • pulmonary interstitial emphysema (RR 0.60)
  • neonatal mortality (RR 0.84)
  • chronic lung disease at 36 weeks’ gestation (RR 0.69).

Reference: Bahadue, F.L., Soll, R., 2012. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database of Systematic Reviews, Issue 11. Art. No: CD001456.  6 RCTs.

Previously published: 19/02/14, 31/07/15

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