Tip 70: hyponatraemia

Hyponatraemia is common in preterm babies, with up to a third of very low birth weight infants being hyponatraemic in the first week after birth.

This is commonly due to: impaired reabsorption of sodium at the proximal tubule; immature up-and-down regulatory mechanisms of Na+/K+/ATP pump; limited aldosterone responsiveness at the distal tubule. Intestinal absorption is also limited.

Reference: Modi, N., 1998. Hyponatraemia in the newborn. Arch Dis Child Fetal Neonatal Ed 1998; 78: F81-F84.

Previously published: 20/03/14, 02/02/15

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