Tip 142: dobutamine

Dobutamine is a cardio-selective synthetic analogue of isoprenaline. It possesses both inotropic (beta-1 adrenergic stimulation) and chronotropic (beta-2 adrenergic stimulation) properties.

It increases cardiac output by increasing myocardial contractility and stroke volume and causes peripheral vasodilatation. Thus, it is a preferred agent for infants with poor cardiac output, myocardial dysfunction and increased systemic vascular resistance, e.g. HIE.

Reference:  Patwardhan, K. (2009). Inotropes in term neonates. Infant5(1), 12.

Previously published: 16/07/14

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