Dobutamine is a cardio-selective synthetic analogue of isoprenaline. It possesses both inotropic (beta-1 adrenergic stimulation) and chronotropic (beta-2 adrenergic stimulation) properties.
It increases cardiac output by increasing myocardial contractility and stroke volume and causes peripheral vasodilatation. Thus, it is a preferred agent for infants with poor cardiac output, myocardial dysfunction and increased systemic vascular resistance, e.g. HIE.
Previously published: 16/07/14