Tip 153: oxygen saturation limits

Pretem infants saturations are kept at 91-95%. Higher levels (95-98%) have been trialed with no evidence of improvement in neurodevelopmental outcomes but worsening ROP outcomes. Lower levels of oxygen (85-89%) have been trialed in the SUPPORT and BOOST 2 studies but found increased mortality in the lower saturation group.

References:

Askie et al (2003). Oxygen-Saturation Targets and Outcomes in Extremely Preterm Infants. N Engl J Med; 349:959-967

Stenson, B. J., Tarnow-Mordi, W. O., Darlow, B. A., … & Armstrong, N. (2013). Oxygen saturation and outcomes in preterm infants. N Engl J Med368(22), 2094-104.

Previously published: 08/08/14

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