PulseOx is a large multicentre UK study of pulse oximetry screening (~20,000 neonates >35/40).
53 had major congenital heart disease (24 critical), a prevalence of 2·6/1000 live births. 35 were suspected from antenatal ultrasound scan. After excluding these, the sensitivity of pulse oximetry to detect congenital heart disease was 58% (28 – 85) for critical cases and 29% (15 – 46) for all cases.
Reference: Ewer, A. K., Middleton, L. J., Furmston, A. T., Bhoyar, A., Daniels, J. P., Thangaratinam, S., … & Khan, K. S. (2011). Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. The Lancet, 378(9793), 785-794.
Previously published: 28/08/14