Tip 161: the COIN trial

COIN is CPAP OINtubation at birth for babies born at 25+0 – 28+6 weeks’ gestation.

There was no significant difference in the combined outcome of death or BPD at 36/40.

In the CPAP group, there were fewer days of assisted ventilation and a lower risk of death or need for O2 at 28 days (64.4% vs 75.6%, OR 0.58 (0.41-0.83)). This is more significant in those born 27 – 28+6 weeks gestation. On the contrary, the pneumothorax rate was higher in the CPAP group (9.3% vs 3%, p=0.001).

Reference: Morley CJ, Davis PG, Doyle LW et al. ‘Nasal CPAP or Intubation at Birth for Very Preterm Infants.’ N Engl J Med 2008; 358:700-708. DOI: 10.1056/NEJMoa072788. Multicentre RCT. 610 infants.

Previously published: 09/09/14

Advertisements
This entry was posted in Respiratory, Trials. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s