Tip 207: Hirshprung’s disease

Hirschsprung’s disease is caused by the failed migration of colonic ganglion cells during gestation. Varying lengths of the distal colon are unable to relax, causing functional colonic obstruction. It most commonly involves the rectosigmoid region of the colon but can affect the entire colon and, rarely, the small intestine.

Reference: Kessmann, J. (2006). Hirschsprung’s Disease: Diagnosis and Management. Am Fam Physician; 74(8): 1319-1322.

Previously published: 30/12/14

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