Treatment of a symptomatic PDA in a preterm infant is usually by fluid restriction (and waiting for spontaneous closure) or ibuprofen (indomethacin is no longer available in the UK.)
The Cochrane review below included the following findings.
- IV ibuprofen showed a reduction in failure rate to close PDA compared with placebo (RR 0.71 (95% CI 0.51 – 0.99)). 1 study, 134 babies.
- Ibuprofen is as effective as indomethacin in closing a PDA, and has a reduced risk of NEC (RR 0.64 (95% CI 0.45 to 0.93)). 16 studies, 948 babies.
Reference: Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database of Systematic Reviews 2015, Issue 2. Art. No.: CD003481. DOI: 10.1002/14651858.CD003481.pub6., , .