Category Archives: Haematology

Tip 37: the PINT study

This study compared low and high haemoglobin thresholds for packed red blood cell (RBC) transfusion in premature infants <1000g. Thresholds were decided by days of age, type of sample and the presence or absence of respiratory support. The high thresholds … Continue reading

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Tip 35b: NAIT

There is a high risk of intra-cranial haemorrhage, so cranial USS should always be done & plts maintained >30 x 109/L (or >50 if evidence of bleeding) with HPA-1a-negative plts. Reference: Chakravorty, S. and Roberts, I., 2012. How I manage neonatal … Continue reading

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Tip 35a: NAIT

Neonatal alloimmune thrombocytopenia (NAIT) is the platelet version of haemolytic disease of the newborn, occuring in 1:1000 – 1:1500 pregnancies. The most common antibody is anti-HPA-1a. Reference: Chakravorty, S. and Roberts, I., 2012. How I manage neonatal thrombocytopenia. British Journal of Haematology, 156(2), … Continue reading

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Tip 34b: thrombocytopenia (term)

Early-onset thrombocytopenia  (<72h, plts <150 x 109/L) in term infants (especially if  plts <50) needs investigating as it is more likely to be due to neonatal alloimmune thrombocytopenia (NAIT) which carries a high risk of intra-cranial haemorrhage. Reference: Chakravorty, S. and Roberts, … Continue reading

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Tip 34a: thrombocytopenia (preterm)

Early-onset thrombocytopenia (<72h, plts <150 x 109/L) in preterm infants is most likely due to placental insufficiency, perinatal asphyxia, perinatal or congenital infection, and should resolve within 14 days. Reference: Chakravorty, S. and Roberts, I., 2012. How I manage neonatal … Continue reading

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Tip 18: blood pressure

As a rough guide, the 5th centile mean arterial blood pressure (mmHg) of a preterm infant is equal to the gestational age in weeks. The 50th centile is +10mmHg. The 95th centile is another +10mmHg. Reference: Rennie & Roberton’s Textbook … Continue reading

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Tip 4: neutropenia

Neutropenia is often defined as <1.1 x 109/L. The incidence increases with decreasing birth weight, seen in 3% term infants weighing >2500g and up to 38% of those weighing <1000g. Reference: Nittala, S., Subbarao, G. C., & Maheshwari, A. (2012). Evaluation … Continue reading

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