Category Archives: Infection

Tip 33b: congenital CMV

>90% infants with infection are asymptomatic but can still develop sensorineural hearing loss. Other symptoms/signs are: IUGR, microcephaly,  thrombocytopenia, jaundice, hepatitis, pneumonitis, periventricular calcification, chorioretinitis and cataracts. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill. Advertisements

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Tip 33a: congenital cytomegalovirus (CMV)

In the UK, 50% women in antenatal clinics are seropositive for CMV. Incidence of congenital CMV infection is ~3 in 1,000 live births. Placental transmission rates are ~40% during primary infection and 1% for reactivated infection. The earlier the gestation … Continue reading

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Tip 24: congenital toxoplasmosis

Severity of infection is worst in the first trimester with intracranial calcification and ventriculomegaly being poor prognostic signs. Mostly though, prognosis is good, especially with antiparasitic treatment following fetal diagnosis on amniocentesis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, … Continue reading

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Tip 19b: congenital rubella syndrome

In the presence of maternal infection, transmission is ~50% in the first month of pregnancy, reducing to 10% in the third month of pregnancy. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 19a: congenital rubella syndrome

The classical trial of congenital rubella syndrome consists of: cataracts, deafness and congenital heart defects (especially pulmonary stenosis). Other features include: microcephaly, developmental delay, jaundice, thrombocytopenia and osteitis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 4: neutropenia

Neutropenia is often defined as <1.1 x 109/L. The incidence increases with decreasing birth weight, seen in 3% term infants weighing >2500g and up to 38% of those weighing <1000g. Reference: Nittala, S., Subbarao, G. C., & Maheshwari, A. (2012). Evaluation … Continue reading

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Tip 250: routine hepatitis B immunisation

In September/October 2017, Hepatitis B vaccine will be added to the routine immunisation schedule at 2, 3 and 4 months of age. This will be done by replacing the existing pentavalent vaccine with a new hexavalent vaccine (Infanrix hexa® (DTaP/IPV/Hib/HepB). … Continue reading

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