Category Archives: Infection

Tip 19b: congenital rubella syndrome

In the presence of maternal infection, transmission is ~50% in the first month of pregnancy, reducing to 10% in the third month of pregnancy. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 19a: congenital rubella syndrome

The classical trial of congenital rubella syndrome consists of: cataracts, deafness and congenital heart defects (especially pulmonary stenosis). Other features include: microcephaly, developmental delay, jaundice, thrombocytopenia and osteitis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 4: neutropenia

Neutropenia is often defined as <1.1 x 109/L. The incidence increases with decreasing birth weight, seen in 3% term infants weighing >2500g and up to 38% of those weighing <1000g. Reference: Nittala, S., Subbarao, G. C., & Maheshwari, A. (2012). Evaluation … Continue reading

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Tip 250: routine hepatitis B immunisation

In September/October 2017, Hepatitis B vaccine will be added to the routine immunisation schedule at 2, 3 and 4 months of age. This will be done by replacing the existing pentavalent vaccine with a new hexavalent vaccine (Infanrix hexa® (DTaP/IPV/Hib/HepB). … Continue reading

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Tip 3: Meningococcal B immunisation

In 2015 MenB vaccine was added to the UK immunisation schedule at 2 months, 4 months and 12 months of age. MenB vaccine should be accompanied by prophylactic paracetamol (3 doses from the time of vaccination unless contra-indicated) at 2 months … Continue reading

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Tip 242: acute liver failure 3

About 60% of deaths in acute liver failure have been attributed to sepsis. The most common organism is Staphylococcus aureus. Other organisms are: Streptococci, coliforms and Candida species. Reference: Dhawan, A., & Mieli-Vergani, G. (2005). Acute liver failure in neonates. Early Human … Continue reading

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Tip 234: chorioamnionitis

Chorioamnionitis is infection of the amniotic fluid, membranes, placenta, and/or decidua. It is a major risk factor for neonatal sepsis. Diagnosis is sometimes made by the presence of maternal fever alone, but for research purposes is defined by the presence of … Continue reading

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