Category Archives: Trials

Tip 226: Back to Sleep campaign 2

Safer sleep encompasses all of the following for the baby: Put on their back to sleep Feet to the foot of the cot No pillow Loose bedding, not covering head Firm, flat, waterproof mattress Separate cot or basket in same … Continue reading

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Tip 225: Back to Sleep campaign

The “Back to Sleep” advice campaign (UK, 1990) to put babies to sleep on their backs is one of the main reasons why sudden infant death syndrome (SIDS) dropped by more than 50% between 1989 (1,545 cases) and 1992 (647 cases). External … Continue reading

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Tip 178: early corticosteroids for CLD

The use of early (< 8 days) corticosteroids reduced death or CLD at 28 days (RR 0.92 [0.88-0.96]) and at 36 weeks (RR 0.89 [0.84-0.95]). Other short-term benefits were successful extubation and closure of PDA. Statistically significant short-term negative effects were: hyperglycaemia, … Continue reading

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Tip 161: the COIN trial

COIN is CPAP Or INtubation at birth for babies born at 25+0 – 28+6 weeks’ gestation. There was no significant difference in the combined outcome of death or BPD at 36/40. In the CPAP group, there were fewer days of assisted ventilation and a … Continue reading

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Tip 159: pulse oximetry screening

PulseOx is a large multicentre UK study of pulse oximetry screening (~20,000 neonates >35/40). 53 had major congenital heart disease (24 critical), a prevalence of 2·6/1000 live births. 35 were suspected from antenatal ultrasound scan. After excluding these, the sensitivity of pulse … Continue reading

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Tip 100: NEOPAIN study 2

Among neonates who did not receive any open-label morphine, severe IVH (p=0·02) occurred more frequently in the morphine group than in the placebo group. However, intermittent boluses of morphine in the placebo group were associated with an even greater frequency … Continue reading

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Tip 99: NEOPAIN study 1

This stratified RCT consisted of 898 ventilated preterm infants (23 – 32 weeks gestation), randomised to continuous morphine infusion or placebo, with open-label morphine boluses given, dependent on clinical judgement. The use of morphine infusion was significantly associated with hypotension, … Continue reading

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