Category Archives: Trials

Tip 99: NEOPAIN study 1

This stratified RCT consisted of 898 ventilated preterm infants (23 – 32 weeks gestation), randomised to continuous morphine infusion or placebo, with open-label morphine boluses given, dependent on clinical judgement. The use of morphine infusion was significantly associated with hypotension, … Continue reading

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Tip 89: probiotics

The use of probiotics in very low birthweight preterm infants: decreases severe NEC (RR 0.57, CI 0.47 – 0.70) mortality (RR 0.77, 0.65 – 0.92) late onset sepsis (RR 0.88, 0.80 – 0.97).   Reference: Dermyshi E, Wang Y, Yan … Continue reading

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Tip 88: lactoferrin supplementation

A systematic review suggests that lactoferrin supplementation to enteral feeds, with or without probiotics, decreases late-onset sepsis and NEC stage 2 or 3 in preterm infants without adverse effects (low quality evidence). New trials of >6000 preterm babies are being completed. … Continue reading

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Tip 37: the PINT study

This study compared low and high haemoglobin thresholds for packed red blood cell (RBC) transfusion in premature infants <1000g. Thresholds were decided by days of age, type of sample and the presence or absence of respiratory support. The high thresholds … Continue reading

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Tip 36: sucrose as analgesia

A Cochrane review showed that oral sucrose (with or without non-nutritive sucking) significantly reduced pain scores associated with heel lancing, venepuncture and IM injections but not ROP screening. The effects on extremely preterm infants or the long-term effects on any … Continue reading

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Tip 31: delayed cord clamping

Delayed cord clamping (>1 min) in healthy term infants leads to higher birthweight, early haemoglobin concentration and increased iron reserves up to six months after birth. However, there is also an increased risk of jaundice requiring phototherapy. Reference:  McDonald SJ, … Continue reading

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Tip 226: Back to Sleep campaign 2

Safer sleep encompasses all of the following for the baby: Put on their back to sleep Feet to the foot of the cot No pillow Loose bedding, not covering head Firm, flat, waterproof mattress Separate cot or basket in same … Continue reading

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