Category Archives: Antenatal

Tip 44b: antenatal magnesium sulphate

There was a reduction in cerebral palsy in children born to women at risk of preterm birth who received magnesium sulphate for neuroprotection of the fetus compared with placebo (RR 0.68, 95% CI 0.54 to 0.87; five RCTs; 6145 children). … Continue reading

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Tip 44a: antenatal magnesium sulphate

IV magnesium sulfate for neuroprotection of the baby should be given to women between 24+0 and 29+6 weeks of pregnancy who are in established preterm labour or having a planned preterm birth within 24 hours. It should be considered up to 33+6 weeks. … Continue reading

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Tip 41: congenital heart disease

The prevalence of structural congenital heart disease is approximately 5 per 1,000 total births (~0.5%). The antenatal diagnosis of serious congenital heart disease is only 50%. The incidence of heart murmurs on day 1 examination, however, may be as high as … Continue reading

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Tip 33b: congenital CMV

>90% infants with infection are asymptomatic but can still develop sensorineural hearing loss. Other symptoms/signs are: IUGR, microcephaly,  thrombocytopenia, jaundice, hepatitis, pneumonitis, periventricular calcification, chorioretinitis and cataracts. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 33a: congenital cytomegalovirus (CMV)

In the UK, 50% women in antenatal clinics are seropositive for CMV. Incidence of congenital CMV infection is ~3 in 1,000 live births. Placental transmission rates are ~40% during primary infection and 1% for reactivated infection. The earlier the gestation … Continue reading

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Tip 24: congenital toxoplasmosis

Severity of infection is worst in the first trimester with intracranial calcification and ventriculomegaly being poor prognostic signs. Mostly though, prognosis is good, especially with antiparasitic treatment following fetal diagnosis on amniocentesis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, … Continue reading

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Tip 21b: maternal diabetes

The rates of all of the following are significantly higher in women with diabetes or their babies compared to matched controls: Preterm birth (31% vs. 10%) Macrosomia (41% vs. 16%) Hypoglycaemia (14% vs. 1%) Jaundice (46% vs. 23%) Respiratory distress (12% vs. 1%). … Continue reading

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