Category Archives: Antenatal

Tip 33b: congenital CMV

>90% infants with infection are asymptomatic but can still develop sensorineural hearing loss. Other symptoms/signs are: IUGR, microcephaly,  thrombocytopenia, jaundice, hepatitis, pneumonitis, periventricular calcification, chorioretinitis and cataracts. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill. Advertisements

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Tip 33a: congenital cytomegalovirus (CMV)

In the UK, 50% women in antenatal clinics are seropositive for CMV. Incidence of congenital CMV infection is ~3 in 1,000 live births. Placental transmission rates are ~40% during primary infection and 1% for reactivated infection. The earlier the gestation … Continue reading

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Tip 24: congenital toxoplasmosis

Severity of infection is worst in the first trimester with intracranial calcification and ventriculomegaly being poor prognostic signs. Mostly though, prognosis is good, especially with antiparasitic treatment following fetal diagnosis on amniocentesis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, … Continue reading

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Tip 21b: maternal diabetes

The rates of all of the following are significantly higher in women with diabetes or their babies compared to matched controls: Preterm birth (31% vs. 10%) Macrosomia (41% vs. 16%) Hypoglycaemia (14% vs. 1%) Jaundice (46% vs. 23%) Respiratory distress (12% vs. 1%). … Continue reading

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Tip 21a: maternal diabetes

~5% of all pregnancies involve women with diabetes. Nearly 90% of these are due to gestational diabetes. Reference: National Institute for Health and Care Excellence (2015).  Diabetes in pregnancy: management of diabetes and its complications from preconception to the postnatal period. … Continue reading

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Tip 19b: congenital rubella syndrome

In the presence of maternal infection, transmission is ~50% in the first month of pregnancy, reducing to 10% in the third month of pregnancy. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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Tip 19a: congenital rubella syndrome

The classical trial of congenital rubella syndrome consists of: cataracts, deafness and congenital heart defects (especially pulmonary stenosis). Other features include: microcephaly, developmental delay, jaundice, thrombocytopenia and osteitis. Reference: Rennie & Roberton’s Textbook of Neonatology, 5th Ed, 2005. London: Churchill.

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