Tip 205: neonatal thyrotoxicosis 2

Hyperthyroidism in the newborn is usually due to transplacental passage of thyroid stimulating immunoglobulins from a mother with Graves’ disease, or, more rarely, Hashimoto’s thyroiditis. It is transient, limited by the clearance of maternal antibody from the baby’s circulation.

The prevalence of Graves’ disease in pregnant women is approximately 0.2%. Although usually only 2–10% of their offspring will have hyperthyroidism.

Reference: Ogilvy-Stuart, A. (2002). Neonatal thyroid disorders. Archives of disease in childhood fetal and neonatal edition, 87(3), F165-F171.

Previously published: 23/12/14